Artificial Organic Chemistry Lab

Molecular catalysts and chemical reactions designed by artificial intelligence with the help of simulations, realized and tested utilizing automated lab protocols.

Our Team

The Pollice Research Group is committed to create an inclusive research environment where members feel safe and respected. We believe that diversity is an intrinsic and important part of the academic community and, therefore, we appreciate differences in backgrounds, experiences and perspectives, and facilitate them to help everyone in our team to reach their full potential in both scientific and non-scientific matters.

Our Research

Our research interests rest on four main pillars. Our primary target is the design of molecular catalysts for organic reactions with the help of computers. To realize that, we combine the simulation of chemical reactions with lab automation for high-throughput experiments and artificial molecular design algorithms. This allows us to incorporate data-driven algorithms directly into our workflow allowing us to accelerate the discovery process.

Latest News


August 1, 2022

Group Launch

On August 1, Rob had his first day at the University of Groningen. First, he was welcomed by fellow faculty, then he took over his new office and finally had a first look at the lab space.

See pictures

Recent Papers

Lab Automation

August 10, 2022

Autonomous Chemical Experiments: Challenges and Perspectives on Establishing a Self-Driving Lab

M. Seifrid, R. Pollice, A. Aguilar-Granda, Z. M. Chan, K. Hotta, C. T. Ser, J. Vestfrid, T. C. Wu, A. Aspuru-Guzik

Acc. Chem. Res. 2022, Advance Article.

Artificial Design

May 3, 2022

Parallel tempered genetic algorithm guided by deep neural networks for inverse molecular design

A. Nigam*, R. Pollice*, A. Aspuru-Guzik

Digital Discovery 2022, 1, 390 - 404.

Molecular Catalysis

January 12, 2022

A Comprehensive Discovery Platform for Organophosphorus Ligands for Catalysis

T. Gensch*, G. d. P. Gomes*, P. Friederich*, E. Peters, T. Gaudin, R. Pollice, K. Jorner, A. Nigam, M. Lindner-D'Addario, M. S. Sigman, A. Aspuru-Guzik

J. Am. Chem. Soc. 2022, 144, 1205 - 1217.